Chordomas are ultra-rare cancers from the axial skeleton with limited treatment options. Chordomas can exhibit immunogenic features, and immune checkpoint blockade has demonstrated clinical activity in some patients, yet the determinants of these responses remain poorly understood. We aimed to elucidate the biological basis of immunogenicity in chordomas through spatial transcriptomic and metabolomic analyses. We applied GeoMx digital spatial profiling…
Immune infiltration is linked to increased transcriptional activity and distinct metabolic profiles in chordomas
bioRxiv Cancer Biology | | van Oost, S., Ursem, R., Erdem, Z. B., Cardoso, S., Venneker, S., van der Breggen, R., Briaire-de Bruijn, I. H., Kruisselbrink, A. B., Peul, W. C., Szuhai, K., van der Wal, R. J. P., van Zeijl, R., Heijs, B., de Miranda, N. F. C. C., Bovee, J. V. M. G.
Topics: immunotherapy