The mechanisms by which Wnt/{beta}-catenin signaling regulates gene expression in a tissue- and context-specific manner remain poorly understood, limiting our ability to target the aberrant cell growth typical of many Wnt-driven cancers. Here we focus on malignant liver tumors driven by activating CTNNB1 ({beta}-catenin) mutations that nevertheless display distinct phenotypic states and Wnt outputs. By profiling patient-derived organoids via single-cell…
Differential Wnt/β-Catenin Signaling via TCF7L2/LEF1 Binding Specificity Shapes Cellular and Tumor Phenotypes
bioRxiv Cancer Biology | | Kluiver, T. A., Nordin, A., Lu, Y., Zhang, C., Schubert, S. A., Duan, X., Savur, R., van den Heuvel, M. C., de Meijer, V. E., de Kleine, R. H., Kraal, K., de Krijger, R. R., Zsiros, J., Cantu, C., Peng, W. C.
Topics: liver-cancer, research