Cathepsins are papain-family cysteine proteases known to play a cell-intrinsic role in protein degradation in the lysosome, as well as in digesting ECM and surface proteins after being secreted. Both of these functions are known to mediate pro-tumorigenic effects of CTSB in a range of cancers. Here, we specifically investigate the role of CTSB in TNBC, an aggressive subtype of…
Cell-line specific role of Cathepsin B in triple-negative breast cancer growth, invasion and response to chemotherapy
bioRxiv Cancer Biology | | Kelley, C., Guarin, J. R., Henrich, E., Fatherree, J. P., Dunn, C. M., Yui, A., Oudin, M. J.
Topics: breast-cancer, blood-cancer, chemotherapy