Re-routing IgE for cancer therapy

<p>Nature Reviews Cancer, Published online: 06 March 2026; <a href="https://www.nature.com/articles/s41568-026-00917-z">doi:10.1038/s41568-026-00917-z</a></p>In a study published in Cell, Xu et al. show that mast cells engineered with tumour-antigen specific antibodies and loaded with an oncolytic virus can be activated by antigen encounter to drive targeted tumour cell killing and amplify local anti-tumour immunity.