Cascade-Targeting Nanoparticles for Reversing Chemoresistance in Osteosarcoma

Osteosarcoma is the most common primary malignant bone tumor in adolescents. Despite significant progress in multimodal therapies, its clinical efficacy remains severely limited by chemotherapy resistance. To overcome the barriers of DNA repair and drug efflux associated with resistance, we developed a biomimetic nanoplatform with cascade targeting capability, termed TAT-mPDO@cRGD-M. This system employs a polydopamine (mPDA) core with strong photothermal…