Oncolytic virotherapy potentiates chemo-PD-1 immunotherapy by engaging chemo-resistant bystander CD8+ T cells

Journal for ImmunoTherapy of Cancer | |

Background <p>The efficacy of combined chemotherapy and programmed cell death protein-1 (PD-1) immune checkpoint blockade (ICB) is constrained by the collateral cytotoxicity of chemotherapy toward proliferating tumor-specific CD8<sup>+</sup> T (T<sub>TST</sub>) cells, a population indispensable for antitumor immunity. This study aimed to overcome this limitation by targeting a potential chemotherapy-resistant immune cell reservoir.</p> Methods <p>By using the murine acutely resolved lymphocytic…

Topics: immunotherapy, chemotherapy, research