Background <p>The efficacy of combined chemotherapy and programmed cell death protein-1 (PD-1) immune checkpoint blockade (ICB) is constrained by the collateral cytotoxicity of chemotherapy toward proliferating tumor-specific CD8<sup>+</sup> T (T<sub>TST</sub>) cells, a population indispensable for antitumor immunity. This study aimed to overcome this limitation by targeting a potential chemotherapy-resistant immune cell reservoir.</p> Methods <p>By using the murine acutely resolved lymphocytic…
Oncolytic virotherapy potentiates chemo-PD-1 immunotherapy by engaging chemo-resistant bystander CD8+ T cells
Journal for ImmunoTherapy of Cancer | | Yang, Y., He, J., Liang, T., Li, K., Lin, Y., Wang, H., Xi, W., Ye, S., Qiu, D., Xie, C., Hao, Y., Li, T., Yue, S., Ye, L., Chen, X.
Topics: immunotherapy, chemotherapy, research
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