Claudin proteins as emerging therapeutic targets for solid tumours

<p>Nature Reviews Cancer, Published online: 02 March 2026; <a href="https://www.nature.com/articles/s41568-026-00913-3">doi:10.1038/s41568-026-00913-3</a></p>In this Review, Saviano et al. explore the frequent deregulation of claudins (CLDNs) in solid tumours and highlight their role in cancer progression. They discuss strategies to target CLDNs by exploiting tumour-specific surface expression or inhibiting oncogenic signalling and outline knowledge gaps, challenges and opportunities for advancing CLDN-directed cancer therapies.