The intestinal microbiota as a key modulator of acute graft-versus-host disease

<p>Nature Reviews Cancer, Published online: 26 February 2026; <a href="https://www.nature.com/articles/s41568-026-00910-6">doi:10.1038/s41568-026-00910-6</a></p>In this Review, Paredes et al. discuss preclinical and clinical evidence suggesting that the intestinal microbiome influences outcomes of allogeneic haematopoietic cell transplantation and, in particular, graft-versus-host disease and propose that microbiota-focused approaches may improve these clinical outcomes.