Background <p>The complex tumor microenvironment (TME) of colorectal cancer (CRC), composed of diverse cellular components and dynamic interactions, constitutes a major barrier to effective immunotherapy and facilitates disease progression. There is a pressing need to elucidate CRC-intrinsic factors that induce the immunosuppressive TME. Here, we explored the role of homeobox D13 (HOXD13) in shaping the immune microenvironment of CRC and…
HOXD13-mediated immune crosstalk between cancer cells and tumor-associated macrophages drives colorectal cancer progression
Journal for ImmunoTherapy of Cancer | | Chen, X., Chen, J., Yin, Y., Sun, M., Li, S., Zhang, J., Wu, Z., Jiang, J., Hu, D., Fan, D., Nie, Y., Huang, W., Wu, K., Xia, L.
Topics: lung-cancer, colorectal-cancer, immunotherapy, new-technology
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