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The path forward for T cell engagers in patients with prostate cancer

Journal for ImmunoTherapy of Cancer | February 24, 2026 | Subudhi, S. K., Siddiqui, B. A., Zarrabi, K. K., Kelly, W. K., Drake, C. G.

Abstract <p>T cell engagers (TCEs) recruit T cells to the tumor microenvironment (TME) to induce antitumor immune responses. TCEs have demonstrated promising clinical responses in patients with metastatic castration-resistant prostate cancer and have advanced into phase 3 clinical trials. Here we provide an overview of the mechanisms of action of TCEs, including both CD3-targeted and CD28-targeted agents, and review the…

Topics: prostate-cancer, clinical-trials, new-technology, research

Read the full article at Journal for ImmunoTherapy of Cancer