Macrophage Mtdh deficiency discordantly regulated tumor growth and metastasis through increased thrombospondin-1 production

Objective <p>Metadherin (MTDH) is a recognized oncogene involved in the progression and metastasis of various cancers. However, further studies are needed to elucidate the biological role of MTDH, which is expressed in macrophages during tumor progression.</p> Methods <p>Mouse colorectal cancer and melanoma cells were subcutaneously and intravenously injected into myeloid-specific <i>Mtdh</i> knockout mice to evaluate tumor growth and lung metastases.…