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Inherited resilience

Nature Reviews Cancer | February 12, 2026 | Daniela Senft

<p>Nature Reviews Cancer, Published online: 10 February 2026; <a href="https://www.nature.com/articles/s41568-026-00914-2">doi:10.1038/s41568-026-00914-2</a></p>Mutant haematopoietic stem cells display broad fitness variation, suggesting that protective mechanisms may limit clonal expansion and malignant transformation. Now, Agarwal et al. identify a germline noncoding variant that confers resilience to clonal haematopoiesis of indeterminate potential (CHIP) by dampening expression of the RNA-binding protein MSI2.

Topics: research

Read the full article at Nature Reviews Cancer