Background <p>The acidic tumor microenvironment (TME) in solid tumors, driven by abnormal metabolism and lactic acid accumulation, suppresses chimeric antigen receptor-T (CAR-T) cell efficacy while posing safety risks from on-target, off-tumor toxicity (OTOT). This study aims to develop a novel CAR-T technology that leverages lactic acid as a tumor-specific trigger to achieve precise control of CAR activity. The objective is…
Harnessing tumor acidity: innovative lactic acid-responsive promoter enables precision control of CAR-T cell activity in solid tumors
Journal for ImmunoTherapy of Cancer | | Feng, M., Zhang, L., Liao, Q., Zhu, L., Zheng, N., Hu, Y., Zhu, C., Mao, Y., Xue, Y., Xia, A., Zhao, C., Ding, X., Zhang, X., Xu, J.
Topics: immunotherapy, new-technology, research
Read the full article at Journal for ImmunoTherapy of Cancer