Background <p>NUT carcinoma is a rare but highly lethal solid tumor without an effective standard of care. NUT carcinoma is caused by bromodomain-containing <i>NUTM1</i> fusion oncogenes, most commonly <i>BRD4::NUTM1</i>. BRD4::NUTM1 recruits p300 to acetylate H3K27 forming expansive stretches of hyperacetylated chromatin called "megadomains" with the overexpression of corresponding oncogenes, including <i>MYC</i>. We hypothesized that transcriptional dysregulation caused by BRD4::NUTM1 would…
Shared PRAME epitopes are T-cell targets in NUT carcinoma
Journal for ImmunoTherapy of Cancer | | Jensen, J. L., Peterson, S. K., Sambade, M. J., Alley, J. R., Yu, S., Kinjo, T., Bennett, S. N., Vensko, S. P., Shabrang, M., Debetta, J. D., Geyer, J. K., Price, B. A., Nickel, K. P., Kimple, R. J., Kotecha, R. S., Herring, L. E., Davis, I. J., Wang, J. R., French, C. A., Kuhlman, B., Weiss, J. M., Rubinsteyn, A., Vincent, B. G.
Topics: blood-cancer, cervical-cancer
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