Background <p>Immunotherapy has had limited success in pancreatic cancer, largely due to a low mutational burden and immunosuppressive microenvironment. Here we hypothesized that systemic delivery of viral antigens can redirect pre-existing antiviral immunity against pancreatic tumors.</p> Methods <p>Cytomegalovirus (CMV, a β-herpesvirus) was chosen, as the majority of the population is infected and it induces an extremely large/broad memory T-cell response.…
Redirecting cytomegalovirus immunity against pancreas cancer for immunotherapy
Journal for ImmunoTherapy of Cancer | | Marrocco, R., Patel, J., Medari, R., Salu, P., Lucero-Meza, E., Maia, C., Brunel, S., Martsinkovskiy, A., Sun, S., Gulay, K., Jaljuli, M., Mose, E., Lowy, A., Benedict, C., Hurtado de Mendoza, T.
Topics: pancreatic-cancer, immunotherapy
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