Background <p>The CDKN2A gene encodes two canonical tumor suppressors, p16INK4A and p14ARF, which safeguard cells from malignant transformation by inducing cell cycle arrest and apoptosis in response to aberrant growth signals. Paradoxically, many cancers overexpress these proteins when downstream effectors that enforce negative feedback regulation are lost or inactivated. For example, p14ARF, which regulates p53 activation, is aberrantly expressed in…
Dysregulated expression of the tumor suppressor p14ARF in cancer provides an effective target for TCR-T cell therapeutics
Journal for ImmunoTherapy of Cancer | | Schmitt, T. M., Furiya, K., Black, C., Vazquez, A., Sharma, J., Hailemariam, M., Paushter, D. H., Trieu, L., Lam, J., Lee, B., Rakhra, K., Whalen, K. A., Mehta, N. K., Sauer, K., Baeuerle, P. A., Michaelson, J. S., Greenberg, P. D., Chapuis, A. G.
Topics: blood-cancer, cervical-cancer
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