Background <p>Myeloid-derived suppressor cells (MDSCs) have a dominating presence in the postoperative period, mediating the suppression of natural killer (NK) cells and promoting cancer metastases after surgery. However, their phenotype and effects on postoperative cellular immunity remain incompletely understood. This study aims to functionally characterize surgery-induced (sx) MDSCs and identify potential therapeutic strategies to mitigate their immunosuppressive effects.</p> Methods <p>We…
Preventing surgery-induced natural killer cell suppression and metastases by inhibiting PI3K-gamma signaling in myeloid-derived suppressor cells
Journal for ImmunoTherapy of Cancer | | Angka, L., Tennakoon, G., Cook, D. P., Martel, A. B., Market, M., Tanese de Souza, C., Cummins, E., Samudio, I., Kekre, N., Ardolino, M., Vanderhyden, B. C., Kennedy, M. A., Auer, R. C.
Topics: blood-cancer, research
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