Background <p>Insufficient infiltration of CD8<sup>+</sup> T cells in the tumor microenvironment (TME) critically restricts antitumor immunity and cancer immunotherapy efficacy. The purpose of this study was to identify novel tumor cell-intrinsic regulators of T-cell infiltration and to elucidate their mechanisms of action.</p> Methods <p>We performed a genome-wide Sleeping Beauty transposon mutagenesis screen in murine breast cancer models. Protein–protein interactions were…
DUSP22 dephosphorylates LGALS1 to enhance T cell-driven antitumor immunity
Journal for ImmunoTherapy of Cancer | | Wang, L., Guo, Y., Dai, Y., Sun, W., Huang, X., Lei, H., Zhang, A., Chen, S., Li, Y., Pan, J., Hong, Y., Ma, L., Feng, Y., Shao, F., Zeng, J., Luo, P., LI, J., Chen, W., Zhou, N., Li, Y., Sun, H., Xu, X., Deng, C.-X., Miao, K.
Topics: breast-cancer, blood-cancer, immunotherapy, new-technology, research
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