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Oncolytic peptide LTX-315 targets PD-L1 to improve antitumor immune response of nanosecond pulse electric field in liver cancer

Journal for ImmunoTherapy of Cancer | January 29, 2026 | Ji, K., Jing, L., Xu, T., Cao, S., Zhang, C., Wang, Z., Zhou, G., Cao, Y., Niu, J., Yang, Y., Chen, X., Ai, J., Sun, J.-H., Xiong, B.

Background <p>Nanosecond pulsed electric field (nsPEF) ablation has demonstrated limited and transient efficacy in suppressing tumor progression. Oncolytic peptide LTX-315 is known to elicit a strong antitumor immune response and durable immune memory. This study aimed to investigate whether LTX-315 could enhance nsPEF-induced antitumor immunity in liver cancer.</p> Methods <p>Both cell assays and mouse models were used to evaluate the…

Topics: liver-cancer, immunotherapy, research

Read the full article at Journal for ImmunoTherapy of Cancer