Background <p>Cancer-associated fibroblasts (CAFs) significantly impact cancer progression and CAF subtypes are key determinants of response to immune checkpoint therapy (ICT). The transforming growth factor-β (TGF-β) signaling is a main pathway in protumorigenic activity of CAFs and resistance to ICT. The actin cytoskeleton regulator hMENA plays crucial roles in epithelial–mesenchymal transition (EMT) and regulates pathways critical to antitumor immune response,…
Reciprocal regulation of hMENA and TGF-{beta} signaling in cancer-associated fibroblasts promotes EMT, immunosuppression, poor prognosis, and ICT resistance in NSCLC
Journal for ImmunoTherapy of Cancer | | Melchionna, R., Di Modugno, F., Di Carlo, A., DAmbrosio, L., Palermo, B., Tocci, A., Paolini, F., Sperduti, I., Campo, G., Taje, R., Gallina, F., Visca, P., DAndrea, D., Nistico, P.
Topics: lung-cancer, immunotherapy, research
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