Introduction <p>An adaptive immune response to cancer requires three main signals: antigen presentation and recognition ("signal 1"), costimulation ("signal 2"), and secreted immunostimulatory cytokines ("signal 3"). Expression of these signals in tumors via non-viral gene delivery represents a promising strategy to reprogram the tumor microenvironment (TME) and prime antitumor immunity.</p> Methods <p>We used modular polymeric poly(beta-amino ester)-based nanoparticles (NPs) to…
Reprogramming the melanoma tumor immune microenvironment via combinatorial signal 2/3 gene delivery
Journal for ImmunoTherapy of Cancer | | Luly, K. M., Zhou, X. M. M., Surwase, S. S., Rocher, E. E., Kollings, J., Lu, C., Will, E., Zhu, Q., Anders, R. A., Green, J. J., Tzeng, S. Y., Sunshine, J. C.
Topics: skin-cancer, new-technology, research
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