Background <p>Oncolytic viruses are tumor-specific immunotherapeutic agents that exploit inherent features of the tumor microenvironment to replicate, spread, and kill cancer cells. The exchange protein activated by cAMP (EPAC) is a cell signaling protein that regulates pathways important for cell growth, survival, and migration, which are commonly associated with cancer progression, but are also very important for regulation of viral…
Oncolytic vaccinia virus encoding constitutively active EPAC remodels the tumor microenvironment to enhance therapeutic efficacy with chemotherapy and surgery
Journal for ImmunoTherapy of Cancer | | Boulton, S., Singh, S., Organ, B., Thomas, J., Rezaei, R., Gill, R., Vallati, S., Guo, Q., Dave, J., Petryk, J., De Souza, C. T., Austin, B., He, X., Gingrich, A., Crupi, M. J. F., Singaravelu, R., Ilkow, C., Bell, J. C.
Topics: cervical-cancer, chemotherapy, new-technology, research
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