Tumour explants as next-generation models of cancer

<p>Nature Reviews Cancer, Published online: 20 January 2026; <a href="https://www.nature.com/articles/s41568-026-00907-1">doi:10.1038/s41568-026-00907-1</a></p>To preserve tumour architecture, cellular heterogeneity and the dynamic crosstalk that influences cancer, Fong and colleagues advocate for coordinated, cross-disciplinary and sustained efforts to promote the widespread adoption of tumour explants.