Background <p>Neoadjuvant immunotherapy has reshaped the treatment paradigm for esophageal squamous cell carcinoma (ESCC), yet mechanisms of resistance in non-responders remain poorly understood. Specifically, the spatial orchestration of the tumor microenvironment that limits effective antitumor immunity is not fully elucidated.</p> Methods <p>Integrating spatial transcriptomic analysis with large-scale tissue pathology, we mapped the spatial architecture of the immune landscape in immunotherapy-resistant…
An Immune-privileged niche mediates immunotherapy resistance in esophageal carcinoma
Journal for ImmunoTherapy of Cancer | | Wan, L., Li, B., Ma, T., Wang, M., Xie, F., Ge, H., Xiao, Z., Chen, X., Meng, L., Zhang, L., Xie, K., Wang, Q.
Topics: blood-cancer, esophageal-cancer, cervical-cancer, immunotherapy, new-technology, research
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