Background <p>Macrophages can eliminate cancer cells through phagocytosis via the CD47/signal regulatory protein α axis, which provides promising targets for cancer immunotherapy as innate immune checkpoints. Although CD47 is overexpressed in multiple cancer types, it remains largely unknown whether and how CD47 can be targeted by manipulating its protein stability.</p> Experimental design <p>Multiple human cancer cell lines were used to…
CD47 destabilization via manipulating the SPOP-USP2 axis augments macrophage phagocytosis and cancer immunotherapy
Journal for ImmunoTherapy of Cancer | | Yan, P., Bu, X., Hou, T., Chen, L., Zhong, G., Huang, D., Wang, J., Qi, Y., Jiang, W., Li, Z., Xue, X., Gao, Y., Liu, J., Inuzuka, H., Freeman, G. J., Wei, W., Dai, X.
Topics: immunotherapy, research
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