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Neutrophil extracellular traps in cancer

Nature Reviews Cancer | November 12, 2025 | Jonathan D. Spicer

<p>Nature Reviews Cancer, Published online: 12 November 2025; <a href="https://www.nature.com/articles/s41568-025-00888-7">doi:10.1038/s41568-025-00888-7</a></p>Neutrophil extracellular traps (NETs) influence cancer initiation, progression and metastasis through immunosuppressive mechanisms within the tumour microenvironment. In this Review, Shahzad et al. highlight our recent understanding of NET biology in cancer and emphasize both the translational data available and the need for further clinical trials evaluating NETs and NET-directed therapies.

Topics: clinical-trials, research

Read the full article at Nature Reviews Cancer