When the time is right

<p>Nature Reviews Cancer, Published online: 09 January 2026; <a href="https://www.nature.com/articles/s41568-025-00904-w">doi:10.1038/s41568-025-00904-w</a></p>In a study published in Nature, Lourenço et al. demonstrate that strong oncogenic driver mutations undergo negative selection unless they occur in a permissive tissue context.