Background <p>Engineering chimeric antigen receptor (CAR) T cells with logic-gated synthetic Notch (synNotch) receptor circuits can enhance specificity and mitigate on-target/off-tumor toxicity. However, the conventional synNotch system uses two lentiviral vectors encoding the synNotch receptor and inducible CAR, requiring dual transduction and cell sorting, which limits clinical translation. Integrating the synNotch-CAR circuit into a single lentiviral vector could overcome this…
Engineering single-vector logic-gated CAR T cells with transgene sizes beyond current limitations
Journal for ImmunoTherapy of Cancer | | Rommel, P. C., Engel, N. W., Malachowski, J. K., Shukla, D., Hodson, I. R., Gonzales, D., van der Loo, J. C. M., Young, R. M., Riley, J. L., Levine, B. L., June, C. H.
Topics: oncology
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