Cannabidiol suppresses emergency MDSCs generation by disturbing EEF1B2-mediated C/EBP{beta} protein synthesis in colorectal adenomas

Background <p>Colorectal cancer often develops from adenomas over years, necessitating early intervention. Myeloid-derived suppressor cells (MDSCs) are major immune suppressive cell types in colon cancer development from adenomas through early inflammation-induced emergency myelopoiesis. Cannabidiol (CBD) is reported to function in psychosis, coronavirus infection and some cancers through immune regulation. However, its target and underlying mechanisms in colorectal adenomas are unknown.</p>…