Background <p>Colorectal cancer (CRC) progression is shaped by the tumor microenvironment, particularly tumor-associated macrophages (TAMs), which often adopt immunosuppressive functions. CD300e, a myeloid receptor involved in immune regulation, has an uncharacterized role in CRC.</p> Methods <p>Functional studies were conducted in azoxymethane/dextran sodium sulfate and MC38 murine CRC models using CD300e systemic and myeloid-specific CD300e knockout mice, and adoptive transfer experiments…
CD300e is a driver of the immunosuppressive tumor microenvironment and colorectal cancer progression via macrophage reprogramming
Journal for ImmunoTherapy of Cancer | | Barizza, A., Vassallo, S., Masatti, L., Laffranchi, M., Giacometti, S., Lonardi, S., Bugatti, M., Coletta, S., Della Bella, C., DElios, M. M., Pizzini, S., Rosato, A., Vermi, W., Fassan, M., Spolverato, G., Sozzani, S., Calura, E., Sommaggio, R., Codolo, G.
Topics: colorectal-cancer, new-technology
Read the full article at Journal for ImmunoTherapy of Cancer