Autologous profiling reveals inter-patient heterogeneity in V{delta}2+{gamma}{delta}TIL responses to glioblastoma driven by extracellular matrix-BTN3A axis

Journal for ImmunoTherapy of Cancer | |

Background <p>The effectiveness of immunotherapies against glioblastoma (GB) remains limited. A major obstacle in advancing new strategies is the reliance on non-autologous systems, which do not accurately mimic the true extent of inter-patient heterogeneity in both immune responses and tumor susceptibility. This often leads to misleading conclusions about therapeutic efficacy and targetability.</p> Methods <p>In this study, we addressed this critical…

Topics: brain-cancer, cervical-cancer, research