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Mechanisms of genomic resistance across emerging classes of KRAS inhibitors

Annals of Oncology | November 7, 2025 | J.M. Riedl, R.B. Corcoran

We appreciate the letter from Castet et al.,1 which comments on our recently published study,2 ‘Genomic landscape of clinically acquired resistance alterations in patients treated with KRASG12C inhibitors,’ and presents an extended comparative analysis of the genomic profile of acquired resistance in patients with pancreatic ductal adenocarcinoma (PDAC) treated with either KRASG12C off-state inhibitors or the novel pan-RAS inhibitor, daraxonrasib.…

Topics: pancreatic-cancer, blood-cancer, cervical-cancer, targeted-therapy, research

Read the full article at Annals of Oncology