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Systemic STING agonist therapy drives expression of interferon stimulated genes and downstream production of cytokines in dogs with solid tumors

Journal for ImmunoTherapy of Cancer | December 14, 2025 | Lenz, J. A., DiBona, J., Atherton, M. J., Roy-Ghanta, S., Schmidt, H., Hart, T., Yu, J. W.

Background <p>Stimulator of interferon genes (STING) agonist drugs can induce expression of interferon stimulated genes (ISGs) and proinflammatory cytokine production aimed to enhance antitumor immunity. The purpose of the current study was to determine the safety, pharmacokinetic, and systemic and intratumoral pharmacodynamic properties of a novel, intravenously delivered STING agonist in client-owned dogs with cancer.</p> Methods <p>GSK856, a small-molecule dimeric…

Topics: skin-cancer, blood-cancer, research

Read the full article at Journal for ImmunoTherapy of Cancer