Background <p>Tumor-associated macrophages (TAMs) abundantly infiltrate tumors and possess potent antitumor capabilities. "Don‘t eat me" signals like CD47 allow tumors to evade macrophages and proliferate unchecked. CD47 is upregulated in many tumors and interacts with the SIRPα expressed on macrophages to restrict effector function. Similarly, CD24 interacts with the Siglec-10 on TAMs to inhibit engulfment. Despite their potential, there is…
Harnessing the innate immune system: a novel bispecific antibody targeting CD47 and CD24 for selective tumor clearance
Journal for ImmunoTherapy of Cancer | | Nan, L., Chen, L., Huang, W., Peng, S., Wang, C., Liao, H., Wang, Y., Cui, Z., Lv, Y., Wang, X., Luo, Y., Tsun, A., Miao, X., Zhang, J.
Topics: blood-cancer, new-technology, research
Read the full article at Journal for ImmunoTherapy of Cancer