Arecoline upregulates CD155 expression to facilitate immune evasion in oral squamous cell carcinoma

Journal for ImmunoTherapy of Cancer | |

Background <p>Areca nut is the fourth most addictive substance worldwide and is a known Group 1 carcinogen. Chronic areca nut chewing has been strongly associated with the development of oral squamous cell carcinoma (OSCC), although the underlying carcinogenic mechanisms remain unclear.</p> Methods <p>Employing spatial multiomics technology, we recently mapped the immune microenvironment of areca nut-associated OSCC and identified a marked…

Topics: cervical-cancer, research