PROTAC-based nanoantigens promote cross-presentation and trafficking of dendritic cell vaccine for enhanced antitumor efficacy

Background <p>As the most powerful professional antigen-presenting cell, dendritic cells (DCs), can effectively activate tumor-specific cytotoxic T lymphocyte responses through antigen cross-presentation (XPT), which involves endosome escape and subsequent degradation by ubiquitin-proteasome system of the exogenous tumor antigen in cytosol. Unfortunately, this important function is often compromised in the tumor microenvironment.</p> Methods <p>To recover the function of DCs in the…