Background <p>Bone metastasis (BM) drives therapeutic resistance and mortality in nasopharyngeal carcinoma (NPC). Tumor metabolites are crucial for NPC metastasis; however, the mechanisms by which these metabolites synergistically alter the immune microenvironment to promote BM remain unclear.</p> Methods <p>In this study, limited immune infiltration was observed in the NPC BM tumor microenvironment. Multiomics analysis has identified sphingosine kinase 1 (SPHK1)…
Aberrant lipid metabolism reshapes the immune landscape in bone metastasis of nasopharyngeal carcinoma
Journal for ImmunoTherapy of Cancer | | Feng, Y., Wang, H., Zhu, Z., Deng, W., He, X., Yao, Y., Song, M., Peng, X., Lin, Y., Cai, L.
Topics: blood-cancer, cervical-cancer, head-neck-cancer, sarcoma, new-technology, research
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