Background <p>High-risk neuroblastoma (HR-NBL) is an aggressive tumor of the sympathetic nervous system with high risk of relapse and poor overall survival. Allogeneic hematopoietic cell transplant (allo-HCT) has been used previously in patients with HR-NBL; however, graft-versus-host disease (GVHD) and disease progression have limited clinical application. Ex vivo stimulated allogeneic natural killer (NK) cells represent an approach to enhance the…
TIM-3 blockade enhances ex vivo stimulated allogeneic NK cell therapy for relapsed murine neuroblastoma after hematopoietic cell transplant
Journal for ImmunoTherapy of Cancer | | Quamine, A. E., Dray, E. L., Mohrdieck, N. R., King, C. A., Griggs, A. A., Kline, J. M., Cho, M. M., Rinella, S. P., Tippins, K. E., Bates, P. D., Shi, L., Song, L., Hess, N. J., Kearl, T. J., Johnson, B. D., Capitini, C. M.
Topics: blood-cancer, pediatric-cancer, clinical-trials
Read the full article at Journal for ImmunoTherapy of Cancer