An unforeseen, existential threat to oncological research in Europe

In this letter, we aim to draw readers’ attention to the existential threat that oncological research in Europe faces due to the unintended consequences arising from the implementation of Regulation (EU) 2017/746 on in vitro diagnostic medical devices (IVDR), and to highlight the ongoing efforts by the European Society for Medical Oncology (ESMO) to mitigate these challenges.