Characterizing population-wide genomic risk distribution for development of a novel clinical-genomic risk system for prognostication in patients with clinically localized prostate cancer

<p>Prostate Cancer and Prostatic Diseases, Published online: 09 December 2025; <a href="https://www.nature.com/articles/s41391-025-01062-8">doi:10.1038/s41391-025-01062-8</a></p>Prostate cancer risk assessment traditionally involves consideration of clinical, pathologic, and genetic factors separately. Combining these factors into single risk assessment system may provide more accurate prediction of outcomes, thereby providing more nuanced and individualized risk prediction.