Being in the zone

<p>Nature Reviews Cancer, Published online: 09 December 2025; <a href="https://www.nature.com/articles/s41568-025-00899-4">doi:10.1038/s41568-025-00899-4</a></p>A study published in Science shows that liver zonation shapes hepatocellular carcinoma (HCC) development. In mice, HCC predominantly originates from zone 3 hepatocytes, where GSTM2 and GSTM3 drive initiation by inhibiting ferroptosis, revealing metabolic vulnerabilities in liver cancer.